The role of macrophage-and dendritic cell-derived IL12 in Th1 phenotype development
A O'Garra, N Hosken, S Macatonia, CA Wenner… - Research in …, 1995 - Elsevier
The class of immune response elicited to antigen determines whether an infectious
organism is eradicated with minimum immunopathology or results in chronic disease, and is
determined by the cytokine profile of the responding CD4+ T cells (Mosmann et al., 1986,
Sher and Coffman, 1992). Furthermore, pathology accompanying inappropriate immune
responses to autoantigens has been associated with production of inflammatory mediators
by CD4+ T cells (Fowell and Mason, 1993; O'Garra and Murphy, 1993; Powrie and Coffman …
organism is eradicated with minimum immunopathology or results in chronic disease, and is
determined by the cytokine profile of the responding CD4+ T cells (Mosmann et al., 1986,
Sher and Coffman, 1992). Furthermore, pathology accompanying inappropriate immune
responses to autoantigens has been associated with production of inflammatory mediators
by CD4+ T cells (Fowell and Mason, 1993; O'Garra and Murphy, 1993; Powrie and Coffman …