The necrosome in acute kidney injury

Y Xu, J Han - Seminars in nephrology, 2016 - Elsevier
Cell death and inflammation in the proximal tubules are the hallmarks of acute kidney injury
(AKI), but the underlying mechanism has not been fully elucidated. Recent evidence has
shown that necroptosis, a type of programmed necrosis, plays an important role in AKI. The
necrosis-inducing signaling complex is called the necrosome, which contains receptor-
interacting protein 1, receptor-interacting protein 3, and mixed lineage kinase domain-like
protein. Studies have found that inhibition of the core components of the necroptotic pathway …