Background G protein-coupled receptors (GPCRs) participate in a variety of physiologic
functions, and several GPCRs have critical physiologic and pathophysiologic roles in the
regulation of renal function. We investigated the role of Gpr97, a newly identified member of
the adhesion GPCR family, in AKI. Methods AKI was induced by ischemia–reperfusion or
cisplatin treatment in Gpr97-deficient mice. We assessed renal injury in these models and in
patients with acute tubular necrosis by histologic examination, and we conducted microarray …