NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen–related cell adhesion molecule 1 signaling
Q Li, Z Wang, Y Zhang, J Zhu, L Li… - Kidney …, 2018 - kidney-international.org
There is significant progress in understanding the structure and function of NLRC5, a
member of the nucleotide oligomerization domain-like receptor family. However, in the
context of MHC class I gene expression, the functions of NLRC5 in innate and adaptive
immune responses beyond the regulation of MHC class I genes remain controversial and
unresolved. In particular, the role of NLRC5 in the kidney is unknown. NLRC5 was
significantly upregulated in the kidney from mice with renal ischemia/reperfusion injury …
member of the nucleotide oligomerization domain-like receptor family. However, in the
context of MHC class I gene expression, the functions of NLRC5 in innate and adaptive
immune responses beyond the regulation of MHC class I genes remain controversial and
unresolved. In particular, the role of NLRC5 in the kidney is unknown. NLRC5 was
significantly upregulated in the kidney from mice with renal ischemia/reperfusion injury …