Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate
that the macrophage is a major contributor to the inflammatory response to AKI. Emerging
data from human biopsies also corroborate the presence of macrophages in AKI and their
persistence in progressive chronic kidney disease. Macrophages are phagocytic innate
immune cells that are important mediators of tissue homeostasis and host defense. In …