A subpopulation of prefrontal cortical neurons is required for social memory
Background The medial prefrontal cortex (mPFC) is essential for social behaviors, yet
whether and how it encodes social memory remains unclear. Methods We combined whole-
cell patch recording, morphological analysis, optogenetic/chemogenetic manipulation, and
the TRAP (targeted recombination in active populations) transgenic mouse tool to study the
social-associated neural populations in the mPFC. Results Fos-TRAPed prefrontal social-
associated neurons are excitatory pyramidal neurons with relatively small soma sizes and …
whether and how it encodes social memory remains unclear. Methods We combined whole-
cell patch recording, morphological analysis, optogenetic/chemogenetic manipulation, and
the TRAP (targeted recombination in active populations) transgenic mouse tool to study the
social-associated neural populations in the mPFC. Results Fos-TRAPed prefrontal social-
associated neurons are excitatory pyramidal neurons with relatively small soma sizes and …