Senescent cells: an emerging target for diseases of ageing

BG Childs, M Gluscevic, DJ Baker… - Nature reviews Drug …, 2017 - nature.com
BG Childs, M Gluscevic, DJ Baker, RM Laberge, D Marquess, J Dananberg…
Nature reviews Drug discovery, 2017nature.com
Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also
promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle
arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism
that also contributes to diseases of late life, including cancer, atherosclerosis and
osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of …
Abstract
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.
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