[HTML][HTML] STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
W Li, X Liang, C Kellendonk, V Poli, R Taub - Journal of Biological …, 2002 - ASBMB
STAT3 is rapidly induced during liver regeneration in an interleukin 6 (IL-6)-dependent
fashion, and IL-6 is required for normal liver regeneration. We wanted to know whether
STAT3 was also required for liver regeneration but disruption of the STAT3 gene during
embryonic stages causes lethality. Therefore, an albumin promoter-driven Cre-loxP
recombination system was used to create a STAT3 deletion in the adult mouse liver to study
the role of STAT3 in liver regeneration. After partial hepatectomy, there was virtually no …
fashion, and IL-6 is required for normal liver regeneration. We wanted to know whether
STAT3 was also required for liver regeneration but disruption of the STAT3 gene during
embryonic stages causes lethality. Therefore, an albumin promoter-driven Cre-loxP
recombination system was used to create a STAT3 deletion in the adult mouse liver to study
the role of STAT3 in liver regeneration. After partial hepatectomy, there was virtually no …