[HTML][HTML] Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes

SH Oh, M Swiderska-Syn, ML Jewell, RT Premont… - Journal of …, 2018 - Elsevier
Background & Aims Chronic failure of mechanisms that promote effective regeneration of
dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar
tissue, ultimately resulting in cirrhosis. Therefore, defining and optimizing mechanisms that
orchestrate effective regeneration might prevent cirrhosis. We hypothesized that effective
regeneration of injured livers requires hepatocytes to evade the growth-inhibitory actions of
TGFβ, since TGFβ signaling inhibits mature hepatocyte growth but drives cirrhosis …