[HTML][HTML] miR-200s contribute to interleukin-6 (IL-6)-induced insulin resistance in hepatocytes
L Dou, T Zhao, L Wang, X Huang, J Jiao, D Gao… - Journal of Biological …, 2013 - ASBMB
By influencing the activity of the PI3K/AKT pathway, IL-6 acts as an important regulator of
hepatic insulin resistance. miR-200s have been shown to control growth by regulating PI3K,
but the role of miR-200s in the development of hepatic insulin resistance remains unclear.
The present study showed that elevated serum concentration of IL-6 is associated with
decreased levels of miR-200s, impaired activation of the AKT/glycogen synthase kinase
(GSK) pathway, and reduced glycogenesis that occurred in the livers of db/db mice. As …
hepatic insulin resistance. miR-200s have been shown to control growth by regulating PI3K,
but the role of miR-200s in the development of hepatic insulin resistance remains unclear.
The present study showed that elevated serum concentration of IL-6 is associated with
decreased levels of miR-200s, impaired activation of the AKT/glycogen synthase kinase
(GSK) pathway, and reduced glycogenesis that occurred in the livers of db/db mice. As …