AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers
BACKGROUND/AIMS: The renin-angiotensin system plays an important role in hepatic
fibrogenesis and in portal hypertension. To examine the long-term effects of Candesartan
cilexetil, an angiotensin type 1 (AT1) receptor blocker, on portal-systemic haemodynamics
and on liver fibrosis. METHODS: Forty-seven compensated Child A and Child B (⩽ 8)
cirrhotic patients were randomly assigned to receive Candesartan cilexetil, 8mg/d (N. 24)
and no treatment (N. 23) for 1 year. Portal-systemic haemodynamic parameters, serological …
fibrogenesis and in portal hypertension. To examine the long-term effects of Candesartan
cilexetil, an angiotensin type 1 (AT1) receptor blocker, on portal-systemic haemodynamics
and on liver fibrosis. METHODS: Forty-seven compensated Child A and Child B (⩽ 8)
cirrhotic patients were randomly assigned to receive Candesartan cilexetil, 8mg/d (N. 24)
and no treatment (N. 23) for 1 year. Portal-systemic haemodynamic parameters, serological …