[HTML][HTML] Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation
T Nagashima, H Shimodaira, K Ide, T Nakakuki… - Journal of biological …, 2007 - ASBMB
ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-
dependent transient and sustained intracellular signaling, proliferation, and differentiation of
MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell
determination mechanism, we investigated time course gene expressions induced by EGF
and HRG that induce distinct cellular phenotypes in MCF-7 cells. To analyze independently
the effects of ligand dosage and time for gene expression, we developed a statistical method …
dependent transient and sustained intracellular signaling, proliferation, and differentiation of
MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell
determination mechanism, we investigated time course gene expressions induced by EGF
and HRG that induce distinct cellular phenotypes in MCF-7 cells. To analyze independently
the effects of ligand dosage and time for gene expression, we developed a statistical method …
