SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets

S Zheng, W Wang, J Aldahdooh… - Genomics …, 2022 - academic.oup.com
Genomics, Proteomics and Bioinformatics, 2022academic.oup.com
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug
combination datasets. Here, we report the major updates to the SynergyFinder R package
for improved interpretation and annotation of drug combination screening results. Unlike the
existing implementations, the updated SynergyFinder R package includes five main
innovations. 1) We extend the mathematical models to higher-order drug combination data …
Abstract
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug combination datasets. Here, we report the major updates to the SynergyFinder R package for improved interpretation and annotation of drug combination screening results. Unlike the existing implementations, the updated SynergyFinder R package includes five main innovations. 1) We extend the mathematical models to higher-order drug combination data analysis and implement dimension reduction techniques for visualizing the synergy landscape. 2) We provide a statistical analysis of drug combination synergy and sensitivity with confidence intervals and P values. 3) We incorporate a synergy barometer to harmonize multiple synergy scoring methods to provide a consensus metric for synergy. 4) We evaluate drug combination synergy and sensitivity to provide an unbiased interpretation of the clinical potential. 5) We enable fast annotation of drugs and cell lines, including their chemical and target information. These annotations will improve the interpretation of the mechanisms of action of drug combinations. To facilitate the use of the R package within the drug discovery community, we also provide a web server at www.synergyfinderplus.org as a user-friendly interface to enable a more flexible and versatile analysis of drug combination data.
Oxford University Press