IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is
mandatory for normal human T-cell development and peripheral homeostasis. Different
studies, including phase I clinical trials, have indicated the potential therapeutic value of
recombinant IL-7 in the context of anti-cancer immunotherapy and as a booster of immune
reconstitution. However, the two main pathways activated by IL-7, JAK/STAT5 and
PI3K/Akt/mTOR, have both been implicated in cancer and there is considerable evidence …
mandatory for normal human T-cell development and peripheral homeostasis. Different
studies, including phase I clinical trials, have indicated the potential therapeutic value of
recombinant IL-7 in the context of anti-cancer immunotherapy and as a booster of immune
reconstitution. However, the two main pathways activated by IL-7, JAK/STAT5 and
PI3K/Akt/mTOR, have both been implicated in cancer and there is considerable evidence …
