Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris …
There is a mutualistic symbiotic relationship between the components of the
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris
(CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC
complex is affected first appears to depend on the type of AMD. In atrophic AMD (∼ 85–90%
of cases), it appears that large confluent drusen formation and hyperpigmentation
(presumably dysfunction in RPE) are the initial insult and the resorption of these drusen and …
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris
(CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC
complex is affected first appears to depend on the type of AMD. In atrophic AMD (∼ 85–90%
of cases), it appears that large confluent drusen formation and hyperpigmentation
(presumably dysfunction in RPE) are the initial insult and the resorption of these drusen and …