Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production
K Nakajima, S Kataoka, K Sato, M Takaishi… - Journal of …, 2019 - Elsevier
Background Psoriasis is an inflammatory disease associated with aberrant crosstalk
between the epidermis and immune system. However, the role of Langerhans cells (LCs) in
psoriasis remains controversial. Objectives To elucidate whether LCs are functionally
involved in the development of psoriasis using a mouse model. Methods Two lines of
transgenic mice were used and crossed. They included K5. Stat3C, the psoriasis-model
mouse and langerin DTR knock-in (KI) mouse. We performed immunofluorescence staining …
between the epidermis and immune system. However, the role of Langerhans cells (LCs) in
psoriasis remains controversial. Objectives To elucidate whether LCs are functionally
involved in the development of psoriasis using a mouse model. Methods Two lines of
transgenic mice were used and crossed. They included K5. Stat3C, the psoriasis-model
mouse and langerin DTR knock-in (KI) mouse. We performed immunofluorescence staining …
