Resident and monocyte-derived Langerhans cells are required for imiquimod-induced psoriasis-like dermatitis model
M Lee, SH Kim, TG Kim, J Park, JW Lee… - Journal of Dermatological …, 2018 - Elsevier
Abstract Background Langerhans cells (LCs) are dendritic cells that reside in the epidermis
and local inflammation results in an increased differentiation of monocyte-derived LCs. Only
few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the
results are variable and the exact role of LCs in psoriasis model remains to be elucidated.
Objective To explore the functional role of resident (rLCs) and monocyte-derived LCs
(mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin …
and local inflammation results in an increased differentiation of monocyte-derived LCs. Only
few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the
results are variable and the exact role of LCs in psoriasis model remains to be elucidated.
Objective To explore the functional role of resident (rLCs) and monocyte-derived LCs
(mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin …