[HTML][HTML] The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy
Y Tanaka, K Tamura, Y Koide, M Sakai, Y Tsurumi… - FEBS letters, 2005 - Elsevier
Y Tanaka, K Tamura, Y Koide, M Sakai, Y Tsurumi, Y Noda, M Umemura, T Ishigami…
FEBS letters, 2005•ElsevierActivation of angiotensin II (Ang II) type 1 receptor (AT1R) signaling is reported to play an
important role in cardiac hypertrophy. We previously cloned a novel molecule interacting
with the AT1R, which we named ATRAP (for Ang II type 1 receptor-associated protein). Here,
we report that overexpression of ATRAP significantly decreases the number of AT1R on the
surface of cardiomyocytes, and also decreases the degree of p38 mitogen-activated protein
kinase phosphorylation, the activity of the c-fos promoter and protein synthesis upon Ang II …
important role in cardiac hypertrophy. We previously cloned a novel molecule interacting
with the AT1R, which we named ATRAP (for Ang II type 1 receptor-associated protein). Here,
we report that overexpression of ATRAP significantly decreases the number of AT1R on the
surface of cardiomyocytes, and also decreases the degree of p38 mitogen-activated protein
kinase phosphorylation, the activity of the c-fos promoter and protein synthesis upon Ang II …
Activation of angiotensin II (Ang II) type 1 receptor (AT1R) signaling is reported to play an important role in cardiac hypertrophy. We previously cloned a novel molecule interacting with the AT1R, which we named ATRAP (for Ang II type 1 receptor-associated protein). Here, we report that overexpression of ATRAP significantly decreases the number of AT1R on the surface of cardiomyocytes, and also decreases the degree of p38 mitogen-activated protein kinase phosphorylation, the activity of the c-fos promoter and protein synthesis upon Ang II treatment. These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes.
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