IL-6, IL-10, c-Jun and STAT3 expression in B-CLL
H Antosz, K Wojciechowska, J Sajewicz… - Blood Cells, Molecules …, 2015 - Elsevier
Chronic lymphocytic leukemia is characterized by the accumulation of functionally abnormal,
monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen,
resulting in a reduction count of normal immunocompetent cells and their impaired immune
function. The defect in transmission of signals from various types of extracellular receptors,
leading to aberrant cytokines and transcription factors gene expression, may underlie the
basis of immune failure in B-CLL. The aim of the study was to assess of IL-6, IL-10, c-Jun …
monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen,
resulting in a reduction count of normal immunocompetent cells and their impaired immune
function. The defect in transmission of signals from various types of extracellular receptors,
leading to aberrant cytokines and transcription factors gene expression, may underlie the
basis of immune failure in B-CLL. The aim of the study was to assess of IL-6, IL-10, c-Jun …
