Importance Oxalate is a potentially toxic terminal metabolite that is eliminated primarily by
the kidneys. Oxalate nephropathy is a well-known complication of rare genetic disorders and
enteric hyperoxaluria, but oxalate has not been investigated as a potential contributor to
more common forms of chronic kidney disease (CKD). Objective To assess whether urinary
oxalate excretion is a risk factor for more rapid progression of CKD toward kidney failure.
Design, Setting, and Participants This prospective cohort study assessed 3123 participants …