HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau
AM Anderson, D Croteau, RJ Ellis, D Rosario… - Journal of …, 2018 - Elsevier
There is mounting evidence that prospective memory (PM) is impaired during HIV infection
despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative)
underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants
had significantly lower PM but significantly higher CSF concentrations of CXCL10 and
quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse
PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau …
despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative)
underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants
had significantly lower PM but significantly higher CSF concentrations of CXCL10 and
quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse
PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau …
