Expression of scavenger receptors in glial cells: comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound β-amyloid
R Alarcón, C Fuenzalida, M Santibáñez… - Journal of Biological …, 2005 - jbc.org
Astrocytes and microglia associate to amyloid plaques, a pathological hallmark of Alzheimer
disease. Microglia are activated by and can phagocytose β-amyloid (Aβ). Scavenger
receptors (SRs) are among the receptors mediating the uptake of fibrillar Aβ in vitro.
However, little is known about the function of the astrocytes surrounding the plaques or the
nature of their interaction with Aβ. It is unknown whether glial cells bind to nonfibrillar Aβ and
if binding of astrocytes to Aβ depends on the same Scavenger receptors described for …
disease. Microglia are activated by and can phagocytose β-amyloid (Aβ). Scavenger
receptors (SRs) are among the receptors mediating the uptake of fibrillar Aβ in vitro.
However, little is known about the function of the astrocytes surrounding the plaques or the
nature of their interaction with Aβ. It is unknown whether glial cells bind to nonfibrillar Aβ and
if binding of astrocytes to Aβ depends on the same Scavenger receptors described for …
