[HTML][HTML] Genetics of eosinophilic esophagitis

LC Kottyan, ME Rothenberg - Mucosal immunology, 2017 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic, allergic disease associated with marked
mucosal eosinophil accumulation. EoE disease risk is multifactorial and includes
environmental and genetic factors. This review will focus on the contribution of genetic
variation to EoE risk, as well as the experimental tools and statistical methodology used to
identify EoE risk loci. Specific disease-risk loci that are shared between EoE and other
allergic diseases (TSLP, LRRC32) or unique to EoE (CAPN14), as well as Mendellian …