A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci

X Chang, M March, F Mentch, K Nguyen… - Journal of Allergy and …, 2022 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the
esophagus marked by eosinophilic infiltration. Cumulative evidence indicates that the risk of
EoE involves the complex interplay of both genetic and environmental factors. Because only
a few genetic loci have been identified in EoE, the genetic underpinning of EoE remains
largely elusive. Objective We sought to identify genetic loci associated with EoE. Methods
Four EoE cohorts were genotyped using the Illumina single nucleotide polymorphism array …