Background A key question in the allergy field is to understand how tissue-specific disease
is manifested. Eosinophilic esophagitis (EoE) is an emerging tissue-specific allergic disease
with an unclear pathogenesis. Objective Herein we tested the hypothesis that a defect in
tissue-specific esophageal genes is an integral part of EoE pathogenesis. Methods We
interrogated the pattern of expression of esophagus-specific signature genes derived from
the Human Protein Atlas in the EoE transcriptome and in EPC2 esophageal epithelial cells …