Prostanoid receptors of the EP4-subtype mediate gene expression changes in human airway epithelial cells with potential anti-inflammatory activity
There is a clear, unmet clinical need to identify new drugs to treat individuals with asthma,
chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) in
whom current medications are either inactive or suboptimal. In preclinical models, EP 4-
receptor agonists display efficacy, but their mechanism of action is unclear. In this study,
using human bronchial epithelial cells as a therapeutically relevant drug target, we
hypothesized that changes in gene expression may play an important role. Several …
chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) in
whom current medications are either inactive or suboptimal. In preclinical models, EP 4-
receptor agonists display efficacy, but their mechanism of action is unclear. In this study,
using human bronchial epithelial cells as a therapeutically relevant drug target, we
hypothesized that changes in gene expression may play an important role. Several …
