Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps
Background IL-25 can function as an early signal for the respiratory type 2 response
characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In
the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human
airway epithelial IL-25 has remained elusive. Objective In this study we sought to determine
whether the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the
sinonasal epithelium. Method Flow cytometry and immunofluorescence for SCCs and IL-25 …
characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In
the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human
airway epithelial IL-25 has remained elusive. Objective In this study we sought to determine
whether the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the
sinonasal epithelium. Method Flow cytometry and immunofluorescence for SCCs and IL-25 …