Life extension in Drosophila by feeding a drug
HL Kang, S Benzer, KT Min - Proceedings of the National …, 2002 - National Acad Sciences
HL Kang, S Benzer, KT Min
Proceedings of the National Academy of Sciences, 2002•National Acad SciencesWe report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can
significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or
reproductive ability. Treatment for a limited period, either early or late in adult life, is also
effective. Flies fed PBA show a global increase in histone acetylation as well as a
dramatically altered pattern of gene expression, including induction or repression of
numerous genes. The delay in aging may result from the altered physiological state.
significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or
reproductive ability. Treatment for a limited period, either early or late in adult life, is also
effective. Flies fed PBA show a global increase in histone acetylation as well as a
dramatically altered pattern of gene expression, including induction or repression of
numerous genes. The delay in aging may result from the altered physiological state.
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
National Acad Sciences