[HTML][HTML] Polyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation

NJ Butcher, GM Broadhurst, RF Minchin - Journal of biological chemistry, 2007 - ASBMB
Spermidine-spermine N 1-acetyltransferase (SSAT) is induced in response to an elevation
in intracellular polyamine pools. The increased enzyme activity is the result of an increase in
gene transcription, mRNA translation, and protein stability. Induction of SSAT by polyamine
analogues can lead to intracellular polyamine depletion and apoptosis. The mechanism by
which polyamines alter the translational efficiency of SSAT mRNA is not well understood. In
this study, we investigated the regulation of SSAT translation by the polyamine analogue N …