[HTML][HTML] Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice …

M Pietilä, L Alhonen, M Halmekytö, P Kanter… - Journal of Biological …, 1997 - ASBMB
We have generated a transgenic mouse line that overexpresses the rate-controlling enzyme
of polyamine catabolism, spermidine/spermineN 1-acetyltransferase. Tissues of these mice
showed markedly distorted polyamine pools, which in most cases were characterized by the
appearance ofN 1-acetylspermidine, not normally found in mouse tissues, a massive
accumulation of putrescine, and decreases in spermidine and/or spermine pools. The most
striking phenotypic change was permanent hair loss at the age of 3 to 4 weeks which was …