[HTML][HTML] A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase

B Joshi, L Li, IR Nabi - Journal of biological chemistry, 2010 - ASBMB
Expression of gp78, an E3 ubiquitin ligase in endoplasmic reticulum-associated
degradation, is associated with tumor malignancy. To study gp78 overexpression in
mammary gland development and tumorigenicity, we generated murine mammary tumor
virus (MMTV) long terminal repeat-driven gp78 transgenic mice. Embryos carrying the gp78
transgene cassette were implanted in FVB surrogate mothers, and two founders with high
copy integration showed elevated gp78 expression at both transcript and protein levels at …