[HTML][HTML] ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

B Ramms, S Patel, C Nora, AR Pessentheiner… - Journal of lipid …, 2019 - ASBMB
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs)
in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on
TRLs and a prominent negative regulator of TG catabolism. We recently established that in
vivo apoC-III predominantly inhibits LDL receptor-mediated and LDL receptor-related
protein 1-mediated hepatic TRL clearance and that apoC-III-enriched TRLs are
preferentially cleared by syndecan-1 (SDC1). In this study, we determined the impact of …