Fibroblasts and synovial immunity
MT Leech, EF Morand - Current opinion in pharmacology, 2013 - Elsevier
Highlights•Synovial fibroblasts are important contributors to inflammation and injury in
RA.•Synovial fibroblasts also contribute to the autoimmune response that drives
RA.•Attention to the role of these cells in RA immunity may reveal new therapeutic
targets.Rheumatoid arthritis (RA) synovium is characterised not only by increases in number
and activity of lymphocytes and macrophages, but also of resident mesenchymal cells
known as fibroblast-like synoviocytes (FLS). Originally thought of as passive structural cells …
RA.•Synovial fibroblasts also contribute to the autoimmune response that drives
RA.•Attention to the role of these cells in RA immunity may reveal new therapeutic
targets.Rheumatoid arthritis (RA) synovium is characterised not only by increases in number
and activity of lymphocytes and macrophages, but also of resident mesenchymal cells
known as fibroblast-like synoviocytes (FLS). Originally thought of as passive structural cells …