[HTML][HTML] AMP is an adenosine A1 receptor agonist
JE Rittiner, I Korboukh, EA Hull-Ryde, J Jin… - Journal of Biological …, 2012 - ASBMB
Numerous receptors for ATP, ADP, and adenosine exist; however, it is currently unknown
whether a receptor for the related nucleotide adenosine 5′-monophosphate (AMP) exists.
Using a novel cell-based assay to visualize adenosine receptor activation in real time, we
found that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5′-
monophosphonate, ACP) directly activated the adenosine A 1 receptor (A 1 R). In contrast,
AMP only activated the adenosine A 2B receptor (A 2B R) after hydrolysis to adenosine by …
whether a receptor for the related nucleotide adenosine 5′-monophosphate (AMP) exists.
Using a novel cell-based assay to visualize adenosine receptor activation in real time, we
found that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5′-
monophosphonate, ACP) directly activated the adenosine A 1 receptor (A 1 R). In contrast,
AMP only activated the adenosine A 2B receptor (A 2B R) after hydrolysis to adenosine by …