[HTML][HTML] cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression
CD39 is a transmembrane enzyme that inhibits platelet reactivity and inflammation by
phosphohydrolyzing ATP and ADP to AMP. Cyclic AMP (cAMP), an essential second
messenger, is particularly important in regulating genes controlling vascular homeostasis.
These experiments test the hypothesis that cAMP might positively regulate the expression of
CD39 and thereby modulate important vascular homeostatic properties. Cd39 mRNA was
induced by 13.8-fold in RAW cells treated with a membrane-permeant cAMP analogue (8 …
phosphohydrolyzing ATP and ADP to AMP. Cyclic AMP (cAMP), an essential second
messenger, is particularly important in regulating genes controlling vascular homeostasis.
These experiments test the hypothesis that cAMP might positively regulate the expression of
CD39 and thereby modulate important vascular homeostatic properties. Cd39 mRNA was
induced by 13.8-fold in RAW cells treated with a membrane-permeant cAMP analogue (8 …