Obesity is associated with metabolic disturbances that cause tissue stress and dysfunction.
Obese individuals are at a greater risk for chronic disease and often present with clinical
parameters of metabolic syndrome (MetS), insulin resistance, and systemic markers of
chronic low-grade inflammation. It has been well established that cells of the immune system
play an important role in the pathogenesis of obesity-and MetS-related chronic diseases, as
evidenced by leukocyte activation and dysfunction in metabolic tissues such as adipose …