Faecalibacterium prausnitzii and human intestinal health
S Miquel, R Martin, O Rossi… - Current opinion in …, 2013 - Elsevier
Current opinion in microbiology, 2013•Elsevier
Highlights•Faecalibacterium prausnitzii is an ubiquitary bacterium of intestinal microbiota of
all animals.•F. prausnitzii is a dominant member of human intestinal microbiota of healthy
adults.•F. prausnitzii is a sensor of health especially for active Crohn's disease
patients.•Beneficial mechanisms and roles of F. prausnitzii in microbiota are still unclear.•F.
prausnitzii is a potential novel probiotic bacterium for human diseases as IBD and
IBS.Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal …
all animals.•F. prausnitzii is a dominant member of human intestinal microbiota of healthy
adults.•F. prausnitzii is a sensor of health especially for active Crohn's disease
patients.•Beneficial mechanisms and roles of F. prausnitzii in microbiota are still unclear.•F.
prausnitzii is a potential novel probiotic bacterium for human diseases as IBD and
IBS.Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal …
Highlights
- Faecalibacterium prausnitzii is an ubiquitary bacterium of intestinal microbiota of all animals.
- F. prausnitzii is a dominant member of human intestinal microbiota of healthy adults.
- F. prausnitzii is a sensor of health especially for active Crohn's disease patients.
- Beneficial mechanisms and roles of F. prausnitzii in microbiota are still unclear.
- F. prausnitzii is a potential novel probiotic bacterium for human diseases as IBD and IBS.
Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
Elsevier