CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish
Z Lin, M Luo, B Zhou, Y Liu, H Sun - Immunology Letters, 2021 - Elsevier
The number and function of T cells are abnormal as observed in cystic fibrosis (CF) patients
and CF mouse models, and our previous work shows that the CFTR mutant leads to
deficiency of primitive and definitive hematopoietic in zebrafish. However, the functions and
underlying mechanisms of CFTR in T cell development during early embryogenesis have
not been explored. Here, we report that the genetic ablation of CFTR in zebrafish resulted in
abrogated embryonic T lymphopoiesis, which was ascribed to impaired thymic homing and …
and CF mouse models, and our previous work shows that the CFTR mutant leads to
deficiency of primitive and definitive hematopoietic in zebrafish. However, the functions and
underlying mechanisms of CFTR in T cell development during early embryogenesis have
not been explored. Here, we report that the genetic ablation of CFTR in zebrafish resulted in
abrogated embryonic T lymphopoiesis, which was ascribed to impaired thymic homing and …