Microglial priming in neurodegenerative disease

VH Perry, C Holmes - Nature Reviews Neurology, 2014 - nature.com
VH Perry, C Holmes
Nature Reviews Neurology, 2014nature.com
Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to
neurodegeneration and the accumulation of abnormally folded proteins, however, microglia
multiply and adopt an activated state—a process referred to as priming. Studies using
preclinical animal models have shown that priming of microglia is driven by changes in their
microenvironment and the release of molecules that drive their proliferation. Priming makes …
Abstract
Under physiological conditions, the number and function of microglia—the resident macrophages of the CNS—is tightly controlled by the local microenvironment. In response to neurodegeneration and the accumulation of abnormally folded proteins, however, microglia multiply and adopt an activated state—a process referred to as priming. Studies using preclinical animal models have shown that priming of microglia is driven by changes in their microenvironment and the release of molecules that drive their proliferation. Priming makes the microglia susceptible to a secondary inflammatory stimulus, which can then trigger an exaggerated inflammatory response. The secondary stimulus can arise within the CNS, but in elderly individuals, the secondary stimulus most commonly arises from a systemic disease with an inflammatory component. The concept of microglial priming, and the subsequent exaggerated response of these cells to secondary systemic inflammation, opens the way to treat neurodegenerative diseases by targeting systemic disease or interrupting the signalling pathways that mediate the CNS response to systemic inflammation. Both lifestyle changes and pharmacological therapies could, therefore, provide efficient means to slow down or halt neurodegeneration.
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