[HTML][HTML] APOL1 nephropathy: from genetics to clinical applications
DJ Friedman, MR Pollak - … Journal of the American Society of …, 2021 - journals.lww.com
Rates of many types of severe kidney disease are much higher in Black individuals than
most other ethnic groups. Much of this disparity can now be attributed to genetic variants in
the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These
variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated
nephropathy, and other forms of nondiabetic kidney disease. We discuss the population
genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then …
most other ethnic groups. Much of this disparity can now be attributed to genetic variants in
the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These
variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated
nephropathy, and other forms of nondiabetic kidney disease. We discuss the population
genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then …