Antigen-specific memory B cell development
LJ McHeyzer-Williams… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract Helper T (Th) cell–regulated B cell immunity progresses in an ordered cascade of
cellular development that culminates in the production of antigen-specific memory B cells.
The recognition of peptide MHC class II complexes on activated antigen-presenting cells is
critical for effective Th cell selection, clonal expansion, and effector Th cell function
development (Phase I). Cognate effector Th cell–B cell interactions then promote the
development of either short-lived plasma cells (PCs) or germinal centers (GCs)(Phase II) …
cellular development that culminates in the production of antigen-specific memory B cells.
The recognition of peptide MHC class II complexes on activated antigen-presenting cells is
critical for effective Th cell selection, clonal expansion, and effector Th cell function
development (Phase I). Cognate effector Th cell–B cell interactions then promote the
development of either short-lived plasma cells (PCs) or germinal centers (GCs)(Phase II) …
