[HTML][HTML] Tumor necrosis factor: an apoptosis JuNKie?
EE Varfolomeev, A Ashkenazi - cell, 2004 - cell.com
EE Varfolomeev, A Ashkenazi
cell, 2004•cell.comTNF's main function is to stimulate inflammation by turning on gene transcription through the
IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through
caspase-8, but the role and underlying mechanism of this activity are not fully understood.
Here, we review recent data on the role of JNK in the regulation of TNF-dependent
apoptosis and discuss what is known so far about how cells decide whether to live or die in
response to TNF.
IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through
caspase-8, but the role and underlying mechanism of this activity are not fully understood.
Here, we review recent data on the role of JNK in the regulation of TNF-dependent
apoptosis and discuss what is known so far about how cells decide whether to live or die in
response to TNF.
Abstract
TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFκB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.
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