[HTML][HTML] Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation
T Loos, G Opdenakker, J Van Damme, P Proost - Haematologica, 2009 - ncbi.nlm.nih.gov
T Loos, G Opdenakker, J Van Damme, P Proost
Haematologica, 2009•ncbi.nlm.nih.govBackground During the first line defense of an infected host, circulating neutrophils invade
the inflamed tissue, whereas mature neutrophils from the bone marrow pool migrate into the
blood circulation and from there reinforce tissue infiltration. The CXC chemokine CXCL8,
also know as interleukin-8, is a potent attractant of neutrophils. Recently, we discovered a
new natural post-translational modification of CXCL8, ie the deimination of arginine into
citrulline by peptidylarginine deiminases.
the inflamed tissue, whereas mature neutrophils from the bone marrow pool migrate into the
blood circulation and from there reinforce tissue infiltration. The CXC chemokine CXCL8,
also know as interleukin-8, is a potent attractant of neutrophils. Recently, we discovered a
new natural post-translational modification of CXCL8, ie the deimination of arginine into
citrulline by peptidylarginine deiminases.
Abstract
Background
During the first line defense of an infected host, circulating neutrophils invade the inflamed tissue, whereas mature neutrophils from the bone marrow pool migrate into the blood circulation and from there reinforce tissue infiltration. The CXC chemokine CXCL8, also know as interleukin-8, is a potent attractant of neutrophils. Recently, we discovered a new natural post-translational modification of CXCL8, ie the deimination of arginine into citrulline by peptidylarginine deiminases.
ncbi.nlm.nih.gov