Blocking TGF-β and β-catenin epithelial crosstalk exacerbates CKD
S Nlandu-Khodo, S Neelisetty, M Phillips… - Journal of the …, 2017 - journals.lww.com
The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how
these growth factors affect the epithelial response to CKD is not well studied. TGF-β has
strong profibrotic effects, but this pleiotropic factor has many different cellular effects
depending on the target cell type. To investigate how TGF-β signaling in the proximal tubule,
a key target and mediator of CKD, alters the response to CKD, we injured mice lacking the
TGF-β type 2 receptor specifically in this epithelial segment. Compared with littermate …
these growth factors affect the epithelial response to CKD is not well studied. TGF-β has
strong profibrotic effects, but this pleiotropic factor has many different cellular effects
depending on the target cell type. To investigate how TGF-β signaling in the proximal tubule,
a key target and mediator of CKD, alters the response to CKD, we injured mice lacking the
TGF-β type 2 receptor specifically in this epithelial segment. Compared with littermate …