Zag expression during aging suppresses proliferation after kidney injury

R Schmitt, A Marlier, LG Cantley - Journal of the American Society …, 2008 - journals.lww.com
Recovery after acute kidney injury is impaired in the elderly, but mechanistic information
regarding why this occurs is limited. In this study, aged mouse kidneys displayed a reduced
epithelial proliferative reserve in vivo and in vitro. Microarray analysis identified increased
expression of zinc-α (2)-glycoprotein (Zag) in aged proximal tubular cells. The addition of
recombinant Zag to primary renal epithelial cell cultures decreased proliferation, whereas
knockdown of Zag increased proliferation. In vivo, systemic small interference RNA …