[HTML][HTML] A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone
I Kakizaki, K Kojima, K Takagaki, M Endo… - Journal of Biological …, 2004 - ASBMB
Specific inhibitors of hyaluronan (HA) biosynthesis can be valuable therapeutic agents to
prevent cancer invasion and metastasis. We have found previously that 4-
methylumbelliferone (MU) inhibits HA synthesis in human skin fibroblasts and in group CS
treptococcus. In this paper, the inhibition mechanism in mammalian cells was investigated
using rat 3Y1 fibroblasts stably expressing HA synthase (HAS) 2. Exposure of the
transfectants to the inhibitor resulted in significant reduction of HA biosynthesis and matrix …
prevent cancer invasion and metastasis. We have found previously that 4-
methylumbelliferone (MU) inhibits HA synthesis in human skin fibroblasts and in group CS
treptococcus. In this paper, the inhibition mechanism in mammalian cells was investigated
using rat 3Y1 fibroblasts stably expressing HA synthase (HAS) 2. Exposure of the
transfectants to the inhibitor resulted in significant reduction of HA biosynthesis and matrix …