Towards a molecular pathway for myoblast fusion in Drosophila
EH Chen, EN Olson - Trends in cell biology, 2004 - cell.com
EH Chen, EN Olson
Trends in cell biology, 2004•cell.comIntercellular fusion among myoblasts is required for the generation of multinucleated muscle
fibers during skeletal muscle development. Recent studies in Drosophila have shed light on
the molecular mechanisms that underlie this process, and a signaling pathway that relays
fusion signals from the cell membrane to the cytoskeleton has emerged. In this article, we
review these recent advances and discuss how Drosophila offers a powerful model system
to study myoblast fusion in vivo.
fibers during skeletal muscle development. Recent studies in Drosophila have shed light on
the molecular mechanisms that underlie this process, and a signaling pathway that relays
fusion signals from the cell membrane to the cytoskeleton has emerged. In this article, we
review these recent advances and discuss how Drosophila offers a powerful model system
to study myoblast fusion in vivo.
Intercellular fusion among myoblasts is required for the generation of multinucleated muscle fibers during skeletal muscle development. Recent studies in Drosophila have shed light on the molecular mechanisms that underlie this process, and a signaling pathway that relays fusion signals from the cell membrane to the cytoskeleton has emerged. In this article, we review these recent advances and discuss how Drosophila offers a powerful model system to study myoblast fusion in vivo.
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