Endothelin/endothelin-B receptor signals regulate ventricle-directed interkinetic nuclear migration of cerebral cortical neural progenitors
K Nishikawa, K Ayukawa, Y Hara, K Wada… - Neurochemistry …, 2011 - Elsevier
We determined the expression profile of∼ 300 G protein-coupled receptors (GPCRs) in
embryonic cortical neural progenitor cells (NPCs) and identified a number of highly
expressed GPCRs, among which endothelin-B receptor (ETB-R) was expressed at the
highest level. We also revealed that endothelins (ETs) were predominantly expressed in
CD31-positive endothelial cells of the embryonic cerebral cortex. Activation of ETB-R
induced NPC assembly in vitro by promoting fibronectin-dependent-motility and N-cadherin …
embryonic cortical neural progenitor cells (NPCs) and identified a number of highly
expressed GPCRs, among which endothelin-B receptor (ETB-R) was expressed at the
highest level. We also revealed that endothelins (ETs) were predominantly expressed in
CD31-positive endothelial cells of the embryonic cerebral cortex. Activation of ETB-R
induced NPC assembly in vitro by promoting fibronectin-dependent-motility and N-cadherin …