Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research
N Masahiko, P Honkakoski - European journal of pharmaceutical sciences, 2000 - Elsevier
N Masahiko, P Honkakoski
European journal of pharmaceutical sciences, 2000•ElsevierRecent findings indicate that induction of drug metabolism is regulated by activation of
specific members of the nuclear receptor gene family. This minireview deals with the
mechanisms by which phenobarbital and phenobarbital-type chemicals induce cytochrome
P450 and other genes, and summarises the knowledge on the role of the constitutively
active receptor CAR in the induction process. The potential implications of CAR-mediated
induction for drug research and possible uses of CAR are also discussed.
specific members of the nuclear receptor gene family. This minireview deals with the
mechanisms by which phenobarbital and phenobarbital-type chemicals induce cytochrome
P450 and other genes, and summarises the knowledge on the role of the constitutively
active receptor CAR in the induction process. The potential implications of CAR-mediated
induction for drug research and possible uses of CAR are also discussed.
Recent findings indicate that induction of drug metabolism is regulated by activation of specific members of the nuclear receptor gene family. This minireview deals with the mechanisms by which phenobarbital and phenobarbital-type chemicals induce cytochrome P450 and other genes, and summarises the knowledge on the role of the constitutively active receptor CAR in the induction process. The potential implications of CAR-mediated induction for drug research and possible uses of CAR are also discussed.
Elsevier