Background: The effects of immunosuppression on responses to SARS-CoV-2 vaccine are unclear given that patients receiving immune-modifying therapies, who constitute 2.8% of commercially insured adults, were underrepresented in vaccine trials (1). Fewer than half of organ transplant recipients receiving antimetabolite therapies developed antibodies after 2 doses of mRNA vaccine (2). Patients with inflammatory bowel disease (IBD) receiving infliximab were less likely than those receiving vedolizumab to develop antibodies after 1 dose of BNT162b2 (Pfizer–BioNTech) or ChAdOx1 nCoV-19 (Oxford–AstraZeneca) vaccine (3), although other researchers have shown that seroconversion occurs in most patients with IBD after 2 doses of mRNA vaccine (4, 5).

Objective: To contextualize these findings relative to nonimmunosuppressed persons by assessing responses after mRNA vaccination in adults with IBD receiving various medication regimens.

Methods: We assessed antibody titers in adults with IBD who received mRNA SARS-CoV-2 vaccination who were referred from 18 US gastroenterology practices and a social media campaign (January to July 2021). Participants completed baseline surveys detailing medical history at the time of vaccination. Local participants at Cedars-Sinai Medical Center were offered antibody assessments after dose 1 (from 5 days after dose 1 until the day of dose 2); after dose 2 (from 2 to 13 days after dose 2); and at 2 weeks (14 to 29 days), 8 weeks (30 to 84 days), and 16 weeks (85 to 140 days) after dose 2; geographically distant participants were offered at-home sampling using Tasso-SST (Tasso) at 8 weeks. We analyzed plasma antibodies to the receptor-binding domain of the spike protein S1 subunit (IgG (S)) and to the viral nucleocapsid protein (IgG (N)) using the SARS-CoV-2 IgG-II and SARS-CoV-2 IgG assays, respectively (Abbott Labs). We defined an IgG (S) level of 50 AU/mL or higher as a positive result. Qualitatively positive responses were determined after dose 1, after dose 2, and after week 2 (14 to 140 days after dose 2). We excluded recipients of the Ad26. COV2 vaccine (Johnson & Johnson), those with prior COVID-19 defined by a positive IgG (N) result at any time point, and those who did not receive both mRNA doses. Participants provided electronic informed consent, and the Cedars-Sinai institutional review board approved the study. Geometric means and CIs were calculated for log-transformed antibody titers.

Findings: The study included 582 participants (mean age, 44 years; 55% female)(Table); 342 (59%) received BNT162b2, and 240 (41%) received mRNA-1273 (Moderna). The proportions of participants receiving no immune suppression, anti-integrin therapy, anti–interleukin-12/23 therapy, immunomodulator monotherapy, anti–tumor necrosis factor monotherapy, Janus kinase inhibition, anti–tumor necrosis factor therapy combined with an immunomodulator, and systemic corticosteroids were 15.8%, 13.7%, 20.4%, 2.1%, 31.4%, 1.2%, 8.6%, and 6.0%, respectively. Those receiving systemic corticosteroids were included in the corticosteroids category regardless of concomitant medications. Four participants were missing medication data. We obtained 854 samples for antibody assessments from 582 participants, including 113 after the first dose, 89 after the second dose, 115 at 2 weeks, 366 at 8 weeks, and 171 at 16 weeks.